![]() ![]() We targeted the TET pathway with two different TET inhibitors, 2-hydroxyglutarate (2HG), a competitive inhibitor of αKG dependent dioxygenases, as well as Bobcat 339, a cytosine based TET inhibitor. We hypothesized that inhibiting the TET enzymes would restore the epigenetic balance in DMG. In our previous studies, we saw that there is an increased TET expression in DMG, while 5hmC was not globally decreased. ![]() The TET enzymes which reduce 5methylcytosine (5mC) to 5hydroxymethylcytosine (5hmC) are essential for removing the methylation marks in the genome. In this study, we investigate the contribution of the Ten Eleven Translocation (TET) enzymes towards this unique epigenetic landscape. DMG, unlike other types of brain tumors, exists in a hypomethylated epigenetic state. Diffuse Midline Glioma, DMG, is one of the worst forms of pediatric brain tumors and is associated with a 100% mortality rate.
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